Dietary and nutraceutical interventions for functional dyspepsia: A narrative review

Functional dyspepsia (FD) is a prevalent disorder of gut-brain interaction. Commonly, meals may exacerbate FD symptoms like postprandial fullness, early satiation, epigastric pain, and nausea. We narratively synthesize meta-analyses, randomized trials, and observational evidence to outline mechanism-based dietary and nutraceutical options. Evidence favors small, regular, lower-fat meals and adjusting texture/osmolarity to minimize gastric distension. In selected phenotypes-particularly postprandial distress with bloating-a brief, dietitian-supervised low-FODMAP trial with staged reintroduction can define personal thresholds. Among nutraceuticals, peppermint-caraway, ginger, STW-5, curcumin, and selected probiotics show benefit, with melatonin and barrier-forming agents promising in subsets, while safety remains product-specific.

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Publication Details

Journal
Digestive and Liver Disease
Published
2026-04-01
DOI
https://doi.org/10.1016/j.dld.2026.03.010
Primary Topic
Gastrointestinal motility and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Dietary and nutraceutical interventions for functional dyspepsia: A narrative review

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Dietary and nutraceutical interventions for functional dyspepsia: A narrative review

Elena Formisano, Giulia Navazzotti, E V Savarino, Edoardo Giovanni Giannini, Vincenzo Savarino, Elisa Marabotto, Francesco Calabrese, Andrea Pasta
article en

Abstract

Functional dyspepsia (FD) is a prevalent disorder of gut-brain interaction. Commonly, meals may exacerbate FD symptoms like postprandial fullness, early satiation, epigastric pain, and nausea. We narratively synthesize meta-analyses, randomized trials, and observational evidence to outline mechanism-based dietary and nutraceutical options. Evidence favors small, regular, lower-fat meals and adjusting texture/osmolarity to minimize gastric distension. In selected phenotypes-particularly postprandial distress with bloating-a brief, dietitian-supervised low-FODMAP trial with staged reintroduction can define personal thresholds. Among nutraceuticals, peppermint-caraway, ginger, STW-5, curcumin, and selected probiotics show benefit, with melatonin and barrier-forming agents promising in subsets, while safety remains product-specific.

Digestive and Liver Disease
University of Padua (IT), Ospedale Policlinico San Martino (IT), University of Genoa (IT)
Zero hunger
Openalex Percentile: Top 21%
Gastrointestinal motility and disorders
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