N,N-Dimethylacetamide exposure induced-acute liver failure

This study aimed to share the case caused by N,N-Dimethylacetamide (DMAC) exposure. We report a 30-year-old man who died from DMAC exposure-induced acute liver failure after working in the cutting and cleansing of hollow fibre membranes for 5 days. While he was exposed to low-level DMAC by inhalation as the measurement of periodic working environment monitoring, considering his working method, considerable DMAC exposure via dermal absorption was suspected. Therefore, short-term, short-latency DMAC exposure via dermal absorption can cause fatal acute liver failure owing to idiosyncratic reactions.

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Publication Details

Journal
Safety and Health at Work
Published
2026-04-01
DOI
https://doi.org/10.1016/j.shaw.2026.03.010
Primary Topic
Carcinogens and Genotoxicity Assessment
Type
article
Field-Weighted Citation Impact
0.00
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article

N,N-Dimethylacetamide exposure induced-acute liver failure

WonYang Kang, Eun Young Kim, Byung-Soon Choi
Safety and Health at Work
Carcinogens and Genotoxicity Assessment
article

N,N-Dimethylacetamide exposure induced-acute liver failure

WonYang Kang, Eun Young Kim, Byung-Soon Choi
article en

Abstract

This study aimed to share the case caused by N,N-Dimethylacetamide (DMAC) exposure. We report a 30-year-old man who died from DMAC exposure-induced acute liver failure after working in the cutting and cleansing of hollow fibre membranes for 5 days. While he was exposed to low-level DMAC by inhalation as the measurement of periodic working environment monitoring, considering his working method, considerable DMAC exposure via dermal absorption was suspected. Therefore, short-term, short-latency DMAC exposure via dermal absorption can cause fatal acute liver failure owing to idiosyncratic reactions.

Safety and Health at Work
Yeoju University (KR)
Openalex Percentile: Top 26%
Carcinogens and Genotoxicity Assessment
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