AN EXPERIMENTAL EVALUATION OF BALYA MAHAKASHAYA ON MENTAL STRENGTH AND PHYSICAL PERFORMANCE IN HEALTHY ALBINO RATS

Balya Mahakashaya, described in Charak Samhita, traditionally indicated for enhancing physical (Sharirika Bala). However its potential role in improving mental strength has not been extensively explored. Thus, a study was designed to evaluate the effect of Balya Mahakashaya (Test formulation) on mental strength in healthy albino rats using In vitro and In vivo experimental models. 78 Healthy albino Wistar rats were selected for the study. Test formulation was administered orally for 15 days consecutively and observations were recorded on Day 0, 5Th and 15th. Statistical analysis was performed using two-way ANNOVA followed by Dunnett’s multiple comparison tests. Motor coordination was assessed using rota rod apparatus, endurance by weight-loaded swim test, and anxiety behavior by light–dark model. The test formulation showed antioxidant activity in DPPH and SOD assays. The acute toxicity studies revealed no mortality or significant toxic effects indicates the safety of the test formulation. The test formulation showed significant improvement in motor coordination and endurance, with minimal effect on anxiety with statistically significant results (p < 0.05). Thus, support its traditional use as a strength-promoting formulation.