FORMULATION AND EVALUTION OF ITRACONAZOLE LOADED MICROSPHERE

Microspheres are novel drug delivery system which a very micro particulate and they are designed in such a way which are aimed in lieu of use in control release DDS. They are made of polymers which may belong from natural, synthetic or semi- synthetic origin. Microspheres are identified by free flowing powder which are particle size ranging from 1-1000µm and having proteins in them. The study suggested that ITCZ-MS was formulated successfully by using double emulsification solvent evaporation method. Upon generating various formulation, F8 was optimized amongst to check various parameters such as % yield, % entrapment efficiency and micromeritic properties. The % yield and % EE was 94%, 86% respectively. The various micromeritic properties was found by means of in range and indicating good flow properties of the powder. The morphological characteristics denoted spherical shape and in range size of the microspheres. The drug release profiles showed that maximum amount of drug was released from the formulation which means that it gave good bioavailability and quick onset of action. The drug release kinetics was best fitted in baker Lonsdale model of drug release kinetics in which drug release mechanism was super case II by erosion method.