ANALYTICAL APPROACHES FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE, TELMISARTAN AND INDAPAMIDE: A COMPREHENSIVE REVIEW

Hypertension is a major chronic cardiovascular disorder affecting large portion of global population. It is characterized by consistently increased force of blood against artery walls. For the long-term management of the hypertension there are multiple single or combination drugs therapy available. Consequently, a triple combination drug containing Amlodipine Besylate (Calcium channel blocker), Telmisartan (Angiotensin II receptor blocker) and Indapamide (Thiazide like Diuretic) is developed. There are formal analytical methods like HPLC, UV, HPTLC, LCMS, UHPLC-UV developed for the estimation of these compounds in single or with other combination dosage form, but not for this particular combination. Which indicates requirement of accurate, precise and sensitive analytical method for the quantitation of the active pharmaceutical compound in pharmaceutical preparation. A well-validated method contributes significantly in maintaining of product quality, safety and therapeutic efficacy. The following study represent the review on official and reported methods available for the antihypertensive drugs Amlodipine besylate, Telmisartan and Indapamide.