Direct optimization of the probability of lesion origin in proton treatment planning for low‐grade glioma patients
POLO model-based treatment plan optimization for LGG patients can be implemented in a technically feasible way, alleviating the need to hand tune the dose and LET<sub>d</sub> distribution. Future work should address multipatient follow-up studies.
Authors
- Julia Bauer (ORCID: https://orcid.org/0000-0002-7944-3757)
- Niklas Wahl (ORCID: https://orcid.org/0000-0002-1451-223X)
- Tim Ortkamp
- Habiba Sallem (ORCID: https://orcid.org/0009-0004-7811-7839)
- Martin Frank (ORCID: https://orcid.org/0000-0001-8562-6982)
- Oliver Jäkel
- Semi Harrabi
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Humboldt-Universität zu Berlin (DE)
- Heidelberger Institut für Radioonkologie (DE)
- Kerntechnische Entsorgung Karlsruhe (Germany) (DE)
Publication Details
- Journal
- Medical Physics
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mp.70395
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft