Distribution characteristics of dyslipidemia in ABO blood groups in Suburbs of Shanghai, China: A cross-sectional study.

ObjectiveTo investigate the distribution features of dyslipidemia within the ABO blood group system Suburbs of Shanghai, China.MethodsThis retrospective cross-sectional study analyzed 12,926 sets of blood lipid data associated with the ABO blood group from January 2018 to December 2024 at Tinglin Hospital in Suburbs of Shanghai. We presented the overall prevalence of dyslipidemia across various ABO blood groups with respect to sex and blood lipid indicators.ResultsAmong the 12,926 individuals included in the study, the overall prevalence of dyslipidemia was 53.44%. The prevalence by blood group was 55.59% in type A, 51.82% in type B, 52.49% in type O, and 54.89% in type AB. Across all blood groups, males consistently showed higher dyslipidemia rates than females, and the sex differences were significant in each ABO group (all P < 0.001).ConclusionIn this hospital-based adult population, dyslipidemia was common and crude prevalence differed modestly across ABO blood groups, with type A showing the highest and type B the lowest prevalence. Across all blood groups, prevalence in male was significantly higher than in female (all P < 0.001). After adjustment for age and sex, adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) indicated higher odds of dyslipidemia for blood group A and lower odds for blood group B compared with group O. However, these comparisons are derived from a retrospective hospital-based dataset and are subject to residual confounding because key lifestyle and clinical factors (e.g., BMI, smoking, comorbidities, and medications) were not available for full adjustment; therefore, the findings should be interpreted as descriptive rather than causal.