Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response
progeria mouse model demonstrates the delayed fracture healing phenotype of naturally aged animal at 3 rather than 20 months of age, we suggest this model provides an accelerated model of age-related delayed fracture healing.
Authors
- Victoria R. Duke (ORCID: https://orcid.org/0000-0001-6949-1862)
- Justin F.M. Hollenbeck (ORCID: https://orcid.org/0000-0003-1682-0444)
- Dustin M. Snapper (ORCID: https://orcid.org/0009-0009-8434-6626)
- Ralph Marcucio (ORCID: https://orcid.org/0000-0002-0537-818X)
- Kohei Yamaura (ORCID: https://orcid.org/0000-0003-2878-1390)
- Matt Huard
- Dane R.G. Lind (ORCID: https://orcid.org/0000-0003-3379-0961)
- Naomasa Fukase (ORCID: https://orcid.org/0000-0001-5688-7673)
- William S. Hambright (ORCID: https://orcid.org/0000-0003-4009-8041)
- Chelsea S. Bahney (ORCID: https://orcid.org/0000-0001-9808-8888)
- Marc J. Philippon (ORCID: https://orcid.org/0000-0002-0358-3331)
- Alex Garcia
- Herbert G. Kasler (ORCID: https://orcid.org/0000-0002-6660-4267)
- Molly Czachor (ORCID: https://orcid.org/0009-0003-3303-9649)
- Jacob D. Matityahu
- Justin Brown
- Anna‐Laura Nelson
- Johnny Huard
Institutions
- Buck Institute for Research on Aging (US)
- University of California, San Francisco (US)
- Steadman Philippon Research Institute (US)
- Kobe University (JP)
Publication Details
- Journal
- Journal of Orthopaedic Research®
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/jor.70193
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Orthopaedic Trauma Association
- National Institutes of Health