Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis

BACKGROUND: -MBW in adults and children/adolescents with CF within the exercise as an airway clearance technique-CF feasibility trial. METHODS: 70% vs <70% predicted). Participants also completed a questionnaire assessing acceptability and willingness to repeat testing. RESULTS: -MBW testing. CONCLUSIONS: represents a robust outcome measure for consideration in CF clinical trials. TRIAL REGISTRATION NUMBER: NCT05482048.

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Publication Details

Journal
BMJ Open Respiratory Research
Published
2026-04-01
DOI
https://doi.org/10.1136/bmjresp-2025-003905
Primary Topic
Cystic Fibrosis Research Advances
Type
article
Field-Weighted Citation Impact
0.00

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article

Measurement of lung clearance index (LCI 2.5 ) by nitrogen multiple breath washout (N 2 -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis

Zoe L. Saynor, S. Cunningham, Mary Abkir, E. L. Taylor et al.
BMJ Open Respiratory Research
Cystic Fibrosis Research Advances
article

Measurement of lung clearance index (LCI 2.5 ) by nitrogen multiple breath washout (N 2 -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis

Zoe L. Saynor, S. Cunningham, Mary Abkir, E. L. Taylor, Donna Bowens, Debbie Miller, Don S Urquhart, Clare J Saunders, Ellen Lacey
article en

Abstract

BACKGROUND: -MBW in adults and children/adolescents with CF within the exercise as an airway clearance technique-CF feasibility trial. METHODS: 70% vs <70% predicted). Participants also completed a questionnaire assessing acceptability and willingness to repeat testing. RESULTS: -MBW testing. CONCLUSIONS: represents a robust outcome measure for consideration in CF clinical trials. TRIAL REGISTRATION NUMBER: NCT05482048.

BMJ Open Respiratory ResearchVol. 13(1)
Western General Hospital (GB), Cystic Fibrosis Trust (GB), Royal Hospital for Children (GB), University Hospital Southampton NHS Foundation Trust (GB), Centre for Inflammation Research (GB), University of Southampton (GB), Imperial College London (GB), University of Edinburgh (GB)
University of Portsmouth, Northumbria University, University Hospital Southampton NHS Foundation Trust, National Institute for Health and Care Research, Department of Health and Social Care, Cystic Fibrosis Trust, Imperial College London
Openalex Percentile: Top 31%
Cystic Fibrosis Research Advances
DOIOpen Access PDFOpenAlex
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Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis — Zoe L. Saynor, S. Cunningham, et al. · BMJ Open Respiratory Research (2026) | TGRS Research Map | TGRS