Thrombin-mediated increased permeability of blood-brain barrier in diquat poisoning: Mechanistic insights and potential therapeutic targets
levels, activating MLCK/MLC2 signaling pathway to impair the BBB, which were mitigated by the endoplasmic reticulum stress inhibitor 4-PBA. In conclusion, DQ increased BBB permeability, with thrombin involvement. These findings offer valuable insights into the mechanisms underlying DQ-induced neurological damage, highlighting potential therapeutic targets for alleviating these effects.
Authors
- Hengbo Gao
- Xu Cao (ORCID: https://orcid.org/0000-0002-9927-6802)
- Changcun Qi
- Bo Song (ORCID: https://orcid.org/0000-0001-5933-7511)
- Xinyu Li (ORCID: https://orcid.org/0000-0001-5136-0303)
- Qing Deng (ORCID: https://orcid.org/0000-0001-9835-6889)
- Qiuyu Yang
- Nan Peng
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2026.120087
- Primary Topic
- Paraquat toxicity studies and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology