Atypical skin involvement as a harbinger of small-cell lung cancer

A male in his late fifties, a chronic smoker, presented to his primary care physician with multiple painless subcutaneous swellings over the torso, which were misdiagnosed as a cutaneous infection for more than a month. Later, he developed haemoptysis for which he presented to our tertiary care subspecialty unit. Further evaluation with imaging revealed a left lung mass with adrenal and gastric lesions, raising suspicion of a lung malignancy with metastasis. A biopsy from a chest wall swelling confirmed primary lung small cell carcinoma with positive synaptophysin expression. Despite timely whole-brain radiotherapy and chemotherapy, his condition deteriorated rapidly, and he succumbed within weeks. This case highlights the rare presentation of small-cell lung carcinoma with cutaneous metastases, which is associated with poor prognosis.

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Publication Details

Journal
BMJ Case Reports
Published
2026-04-01
DOI
https://doi.org/10.1136/bcr-2026-272000
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Atypical skin involvement as a harbinger of small-cell lung cancer

Gayathri Saravanan, Lokesh Saini, Ravi Hari Phulware, Anjana Anilkumar
BMJ Case Reports
Cancer Diagnosis and Treatment
article

Atypical skin involvement as a harbinger of small-cell lung cancer

Gayathri Saravanan, Lokesh Saini, Ravi Hari Phulware, Anjana Anilkumar
article en

Abstract

A male in his late fifties, a chronic smoker, presented to his primary care physician with multiple painless subcutaneous swellings over the torso, which were misdiagnosed as a cutaneous infection for more than a month. Later, he developed haemoptysis for which he presented to our tertiary care subspecialty unit. Further evaluation with imaging revealed a left lung mass with adrenal and gastric lesions, raising suspicion of a lung malignancy with metastasis. A biopsy from a chest wall swelling confirmed primary lung small cell carcinoma with positive synaptophysin expression. Despite timely whole-brain radiotherapy and chemotherapy, his condition deteriorated rapidly, and he succumbed within weeks. This case highlights the rare presentation of small-cell lung carcinoma with cutaneous metastases, which is associated with poor prognosis.

BMJ Case ReportsVol. 19(4)
Seema Dental College and Hospital (IN), All India Institute of Medical Sciences Rishikesh (IN)
No poverty
Openalex Percentile: Top 22%
Cancer Diagnosis and Treatment
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