Magnetic Nanoparticles‐Catalyzed Two‐Component [3 + 2] Cycloaddition Toward Green Syntheses of Tetrazoles: A Review

ABSTRACT Organic synthesis has pushed for more nature‐friendly synthetic techniques toward the development of interesting compounds. Green synthesis lowers or gets rid of harmful chemicals through the use of recyclable or renewable materials. In this context, magnetic nanoparticles have gained popularity in green synthesis over the decade due to their various eco‐friendly features and successful implementation for the development of organic molecules. Tetrazoles are preferred organic compounds employed in the identification of lead structures of many reputed marketed drugs. Medicinal and organic chemists have developed various highly valuable derivatives of tetrazole by using magnetic nanoparticles as green catalysts in [3 + 2] cycloaddition reactions. This methodology has several additional features like high yields, short reaction times, and reusability of the catalyst. This is the first report that summarizes studies on using green magnetic nanoparticles to synthesize a class of tetrazole and its derivatives by the application of [3 + 2] cycloaddition reactions.