Mitochondrial localization around central nuclei in regenerating skeletal muscle following eccentric contraction in rat model
Using PTM and TEM, this study reveals that mitochondrial networks fragment and cluster around central nuclei during muscle regeneration. These perinuclear mitochondria are structurally immature, exhibiting low cristae density. This localization suggests a potential bioenergetic hub that may support the transcriptional and translational demands of muscle differentiation. Thus, this accumulation likely plays a key role in metabolic and organelle coordination during functional muscle repair.
Authors
- Kazuyoshi Yagishita (ORCID: https://orcid.org/0000-0003-3809-8931)
- Yutaka Kano (ORCID: https://orcid.org/0000-0003-0913-9714)
- Ayaka Tabuchi (ORCID: https://orcid.org/0000-0002-2963-8695)
- D. C. Poole
- Daisuke Hoshino (ORCID: https://orcid.org/0000-0003-0065-8470)
- Reiya Murakami
- Takayoshi Kobayashi
Institutions
- Kansas State University (US)
- University of Electro-Communications (JP)
- Institute of Science Tokyo (JP)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1152/ajpcell.00115.2026
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science