Abstract 1246: The comprehensive outcomes for after cancer health (COACH) study: Interim analysis of baseline demographic and patient reported outcome data for individuals with advanced cancer.

Abstract Background: Patients with metastatic cancer face complex self-management challenges requiring symptom monitoring, care coordination, and psychosocial support. Digital tools, including electronic patient-reported outcomes (ePROs), wearables, and health coaching (DHC), have demonstrated improvement outcomes, including overall survival for individuals with cancer, yet less is known about their effect for individuals with advanced breast (aBC) or lung(aLC) cancer. The COACH trial (NCT05349227) evaluates a comprehensive DHC program combining clinical, ePRO, wearable, and gut microbiome data to address survivorship needs in these unique groups. Methods: This multicenter, randomized, wait-list controlled trial enrolls 675 adults (≥18 years) within one year of completing primary therapy or with metastatic disease, across 8 sites. Subpopulations include aBC (n=150) and aLC (n=100). Participants are randomized to 6 months of DHC or control, with crossover at month 6. All participants are provided with activity trackers (Fitbit), complete ePROs over the course of 12 months, and provide fecal microbiome specimens and dietary data at baseline and month 6. Interim Outcomes: As of November 2025, 91 aBC participants have been enrolled, of whom 75 have completed baseline ePRO assessments, and 41.5% have connected their Fitbit device to the cloud for data collection. Baseline PROMIS scores for 61 participants with data available for analysis are presented in the Table. Conclusion: Interim data suggest that individuals with metastatic cancer have numerically higher anxiety and lower cognitive and physical functioning compared to population mean scores. Outcomes from this study will evaluate if and how DHC can be used to address these challenges. Multimodal data derived from this study is intended to enhance understanding of the potentially unique survivorship needs of individuals with advanced cancer. Citation Format: Kelly J. Brassil, Trudy Buckingham, Anneliese Gonzalez, Michael Harrison, Kaukab Jafry, Abbey Kaler, Hilda H. Lewis, Jennifer Loftis, Kathrin Milbury, Darcy Ponce, Michelle Schumacher, Meagan Whisenant, Cosmina Hogea. The comprehensive outcomes for after cancer health (COACH) study: Interim analysis of baseline demographic and patient reported outcome data for individuals with advanced cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 1246.