Itaconic Acid as an Environmentally Benign Catalyst for the Efficient Synthesis of 4,6‐Diarylpyrimidin‐2(1H)‐ones

ABSTRACT The synthesis of 4,6‐diarylpyrimidin‐2(1H)‐one derivatives has been efficiently achieved using Itaconic acid. This organocatalyst is cost‐effective and readily accessible. The reaction is carried out in 2‐propanol as the solvent. Under optimized conditions, a wide range of substituted aromatic aldehydes, aromatic ketones, and urea underwent cyclocondensation. These afford the corresponding 4,6‐diarylpyrimidin‐2(1H)‐one derivatives in high yields. This demonstrates the potential of this method for high‐yield synthesis. The protocol features a broad substrate scope and operational simplicity. It also provides short reaction times and high catalytic efficiency, with significant tolerance toward diverse functional groups. This strategy offers a high‐yielding, sustainable, and practical approach for synthesizing pyrimidinone frameworks.