Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
-associated SVD/VaD, reinforcing the value of patient-specific iPSCs for disease modeling and potential drug discovery.
Authors
- Aite Zhao (ORCID: https://orcid.org/0000-0003-3494-175X)
- Chaowen Yu
- A.R. Adamson
- H. Zhou
- Xiangjun Zhao (ORCID: https://orcid.org/0009-0007-3769-2337)
- Tao Wang
- Pankaj Sharma
Institutions
- Qingdao University of Science and Technology (CN)
- Imperial College Healthcare NHS Trust (GB)
- University of Leicester (GB)
- Royal Free London NHS Foundation Trust (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Science Advances
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1126/sciadv.aeb1134
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- China Scholarship Council