Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF
, is also controlled by uORFs. Thus, regulation of TNFR1 levels and possibly of other immune receptors emerges as a mechanism safeguarding against excessive immune responses and tissue damage.
Authors
- Vinnycius Pereira Almeida (ORCID: https://orcid.org/0000-0002-3635-7787)
- Max B. Sauerland (ORCID: https://orcid.org/0000-0002-6029-7972)
- Wenxin Lyu (ORCID: https://orcid.org/0000-0002-5941-1109)
- Carol Sze Ki Leung (ORCID: https://orcid.org/0000-0002-1545-7228)
- B. Van den Eynde
- John Rizk (ORCID: https://orcid.org/0000-0002-3352-5474)
- Majken Kjær (ORCID: https://orcid.org/0000-0002-3511-2550)
- Malin Jessen (ORCID: https://orcid.org/0009-0007-5929-0064)
- Mads Gyrd-Hansen
- Biao Ma
Institutions
- University of Copenhagen (DK)
- Ludwig Cancer Research (BE)
- University of Oxford (GB)
- Ludwig Cancer Research (GB)
- de Duve Institute (BE)
- LEO Foundation (DK)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1126/sciimmunol.aeb6484
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Cancer Research UK
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Novo Nordisk Fonden
- LEO Fondet