Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule–associated complex requires Pasovec/Gid8 proteins

/β-catenin mutant phenotypes, is required for nuclear β-catenin/Arm localization. Psv interacts with the IFT-A/Kinesin2 complex, physically binding IFT140, a core component of IFT-A. The Psv/Gid8-IFT140 association is independent of Wg/Wnt-signaling activation. Psv/Gid8 contains a CRA domain, identified as interacting with RanBPM, which mediates its nuclear localization. Mutations in CRA affect Psv/Gid8's own nuclear localization and that of β-catenin/Arm upon Wg/Wnt-signaling activation. Psv with a mutated CRA can act as an inhibitor of Wg/Wnt signaling. Together, this study describes a previously unidentified factor, required for Wg/Wnt signaling, that functions during the nuclear translocation process of β-catenin/Arm.