Evolution of fuzzy logic in medical applications: methods, trends and clinical applications

Fuzzy logic techniques have gained significant prominence in healthcare, primarily due to their ability to address and manage the inherent imprecision and uncertainty in healthcare data analysis. We conducted a comprehensive review investigating how fuzzy techniques have developed and been applied in healthcare between 2017 and 2025. We conducted a systematic literature review following PRISMA guidelines, analyzing 91 papers from major medical and engineering databases. Our analysis focused on three distinct methodological streams: classical fuzzy systems, combined fuzzy-machine learning approaches, and emerging fuzzy-enhanced deep learning frameworks. We evaluated each paper’s methodology, implementation details, and clinical relevance. The distribution of research approaches showed a balanced landscape across methodologies, with traditional fuzzy systems comprising 30.1%, hybrid approaches 34.4%, and fuzzy-deep learning implementations 33.3% of studies. Medical imaging dominated the application domains, led by MRI studies (36.3%) and CT applications (12.1%). Biosignal analysis also showed strong representation, particularly in EEG (22%) and ECG (7.7%) applications. Performance analysis revealed that both deep learning and conventional feature engineering methods achieved comparable accuracy rates of approximately 96.5%, with some variations in consistency across different applications. This research area has undergone significant evolution, particularly since 2023, with an increased emphasis on incorporating fuzzy techniques into deep learning frameworks. This transition shows that fuzzy approaches, originally designed as standalone solutions, are now becoming critical components of modern healthcare AI systems, providing unique benefits in dealing with medical data uncertainty.