Loss of Y Chromosome Associates With Lung and Cardiac Dysfunction in <scp>COPD</scp>
This study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanistic basis for sex-biased vulnerability in COPD.
Authors
- Chanil Valasarajan (ORCID: https://orcid.org/0000-0002-0969-9044)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Jochen Wilhelm
- Andreas M. Zeiher (ORCID: https://orcid.org/0000-0003-1711-5819)
- Stefan Kuhnert (ORCID: https://orcid.org/0000-0002-1698-2155)
- Tina Rasper
- Ali Önder Yildirim (ORCID: https://orcid.org/0000-0003-1969-480X)
- S Pullamsetti
- Deepesh Dhakad
- R Savai
- Werner Seeger
- Robert Bals
Institutions
- Goethe University Frankfurt (DE)
- Justus-Liebig-Universität Gießen (DE)
- Frankfurt Institute for Advanced Studies (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- Cardio-Pulmonary Institute (DE)
- Ludwig-Maximilians-Universität München (DE)
- Saarland University (DE)
Publication Details
- Journal
- Comprehensive physiology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/cph4.70142
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Deutsches Zentrum für Lungenforschung
- HORIZON EUROPE European Research Council