Thromboxane A2 synthase is an off target of the CES1 small-molecule inhibitor WWL113

=226 nM). These findings indicate that WWL113, which inhibits CES1 activity and exerts anti-inflammatory effects in vitro and in vivo, can also target TBXAS1. Thus, the beneficial effects of WWL113 observed in diet-induced obese mice may in part be related to its ability to block proinflammatory TxA2 production. It is, therefore, recommended that WWL229 be used instead of WWL113 to perturb CES1 activity in living cells and animal models.