Hijacking competitor-derived signals: RcsB/C drives <i>Lysobacter enzymogenes</i> to exploit farnesol for enhanced antifungal capacity
to convert a fungal communication molecule into a cue that strengthens its antagonistic capacity. We further identify key amino acid residues in RcsC responsible for farnesol recognition, revealing the bacterial two-component system (TCS) known to detect this molecule. These findings expand the functional scope of fungal quorum-sensing signals, uncover a previously unrecognized mechanism of interkingdom antagonism, and provide insights with potential applications in microbiome-based biocontrol.
Authors
- Huihui Song (ORCID: https://orcid.org/0000-0002-1509-966X)
- Zeran Bian (ORCID: https://orcid.org/0000-0001-9111-6241)
- Jie Yin
- Zipeng Lin
- Fang Nan
- Lei Cui
Institutions
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Ocean University of China (CN)
- College of Marin (US)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1128/aem.00304-26
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities