Statins and postmenopausal breast cancer risk; results from the KARMA cohort

PURPOSE: To study the incidence and subtype of breast cancer in relation to incident and prevalent statin use in a contemporary Swedish prospective cohort, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. METHODS: A total of 35,315 postmenopausal women attending mammography and included in the KARMA cohort (Jan 2011-March 2013) with data on statin use and potential confounders were studied. During eight years of follow-up, 785 incident invasive breast cancer cases were identified. RESULTS: 0.90, 95% CI 0.73-1.11, respectively). Similarly, no significant association was found for incident or prevalent statin use and subtype-specific risk of breast cancer. CONCLUSION: This prospective population-based study performed in a modern screening population with a substantial number of statin users, concurs with previous publications showing no evidence of an association between statin use and risk of postmenopausal breast cancer.