Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor
-positive cell burden or improved aging-related health parameters. Although we do not seek to discredit prior work, our results underscore the need for rigorous design, standardized protocols, and independent validation to ensure reliable senolytics before clinical translation.
Authors
- Ken Uemura
- Y. Oike
- Daisuke Torigoe (ORCID: https://orcid.org/0009-0007-9924-4994)
- Naoki Mochizuki (ORCID: https://orcid.org/0000-0002-3938-9602)
- Koyu Ito (ORCID: https://orcid.org/0000-0001-7944-9692)
- Mikako Maruya
- Masataka Sugimoto (ORCID: https://orcid.org/0000-0001-8737-8097)
- A Takahashi
- E. Hara
- Takumi Mikawa (ORCID: https://orcid.org/0000-0003-0980-2379)
- Sho Sugawara (ORCID: https://orcid.org/0000-0003-0010-7409)
- Haruki Horiguchi (ORCID: https://orcid.org/0000-0001-9344-8362)
- Shimpei Kawamoto (ORCID: https://orcid.org/0000-0002-7033-671X)
- Masahiro Wakita
- Yumiko Okumura
- B. Jung (ORCID: https://orcid.org/0009-0007-0017-6996)
- Nozomi Hori
- Jeong Hoon Park
- Hideka Miyagawa
- Xiangyu Zhou
- Hiroshi Kondoh
Institutions
- Tohoku Institute of Technology (JP)
- Tohoku University (JP)
- Kyoto University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Kyoto University Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Center for Geriatrics and Gerontology (JP)
- Japanese Foundation For Cancer Research (JP)
- Kumamoto University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- EMBO Reports
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1038/s44319-026-00740-5
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 19.92
Funders
- Takeda Science Foundation
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Mitsubishi Foundation
- Nagase Science Technology Foundation
- Foundation for Biomedical Research and Innovation
- Lotte Foundation
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency