Abstract 2402: Rapid lead generation with the Pioneer Antibody Discovery Platform.

Abstract The Pioneer™ Antibody Discovery Platform is Bio-Rad’s biotherapeutic antibody generation service, centered around the Pioneer Antibody Library—one of the largest functional Fab libraries (225 billion unique sequences). Informed by over 18 years of phage display expertise, the library is optimized for therapeutic antibody selection. It integrates SpyDisplay, a proprietary SpyTag-based selection system, and TrailBlazer, a modular platform for rapid format assembly. We showcase data on antibody selection against IL-6R, C5aR, and CXCR4, demonstrating that the Pioneer Platform yields diverse, high-affinity, and functional leads for difficult targets. These candidates show comparable or superior performance to clinically developed or marketed antibodies across key parameters. Citation Format: Birthe Jessen-Park, Sarah-Jane Kellmann, Mateusz Putyrski, Manuel Cavada, Hanh Hanuschka, Christian Frisch, Achim Knappik, Francisco Ylera. Rapid lead generation with the Pioneer Antibody Discovery Platform [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 2402.