The Pharmacokinetics and Relative Bioavailability of a Mini‐Tablet of Mercaptopurine, a Novel Formulation for Use in Children with Acute Lymphoblastic Leukemia
/F of 6-MP and decreased exposure of 6-MP, with all changes exceeding two-fold. Both products exhibited a favorable safety profile without any SAE being observed. These results supported the marketing of 6-MP mini-tablets.
Authors
- Yan Yang
- Q Li (ORCID: https://orcid.org/0009-0008-6075-2550)
- Jinyi Shi
- Panpan Ye (ORCID: https://orcid.org/0000-0001-8165-023X)
- Q Liu
- Yue Zhou (ORCID: https://orcid.org/0000-0002-1335-5703)
- John van den Anker (ORCID: https://orcid.org/0000-0002-3585-321X)
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Zhi Chen (ORCID: https://orcid.org/0000-0002-5159-1280)
- Haiyan Zhou
- Ye‐Hui Zhang
- Lin‐lin Song
- Fu‐Rong Zhao
- Wen‐Chao Lu
- Qian Zhao
- Ke‐Guang Chen
- Yuan‐Yuan Zheng
Institutions
- Shandong University (CN)
- China Resources (China) (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- The Journal of Clinical Pharmacology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/jcph.70178
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China