The <i>N</i> -Acylpolyamine Structure Assigned as Parawixin10 Does Not Display Positive Allosteric Modulatory Activity in EAAT1–3 Radioligand Uptake Assays, nor Does It Enhance Neuronal Survival in Mice in a Dose-Dependent and Statistically Significa
(parawixin10) and show here that this compound does not enhance Glu uptake in a wide range of radioligand binding assays, nor does it, in our hands, show any neuroprotective effect in a dose-dependent, statistically significant way.
Authors
- Melissa Schepers (ORCID: https://orcid.org/0000-0001-8090-8489)
- Yasaman Doroudian
- Lennart Bunch (ORCID: https://orcid.org/0000-0002-0180-4639)
- T Vanmierlo
Institutions
- University of Copenhagen (DK)
- Neurosciences Institute (US)
- Maastricht University (NL)
- Hasselt University (BE)
Publication Details
- Journal
- ACS Chemical Neuroscience
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1021/acschemneuro.5c00943
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00