Pd-Catalyzed <i>meta</i> -C–H Arylation Using a Convertible Directing Group: Streamlined Construction of Biaryl Cores of Peptide Natural Products
-biaryl peptide natural products, including biphenomycin, RP-66453, and arylomycin, were efficiently constructed. This work demonstrates the first practical application of a convertible directing group (MIA) in complex natural product synthesis and provides a powerful "skeleton-editing" strategy for accessing biaryl cyclic peptide architectures.
Authors
- Yu‐Peng He (ORCID: https://orcid.org/0000-0002-0676-6627)
- Yue‐Ning Meng
- Peng‐Yu Liu (ORCID: https://orcid.org/0000-0002-3764-1771)
- Gen Li
- Gong Chen
Institutions
- Liaoning Shihua University (CN)
- Nankai University (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
- Zhejiang Pharmaceutical College (CN)
- State Key Laboratory of Fine Chemicals
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1021/acs.orglett.6c00980
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo