First Report of Human Hepatitis B Virus (HBV) in Wild Neotropical Primates

Globalization and environmental change are reshaping infectious disease dynamics, including reverse zoonotic transmission from humans to wildlife. We assessed hepatitis B virus (HBV) infection in wild New World primates from two Brazilian Amazon regions: an anthropogenically impacted area in southwestern Amazonia (Rondonia and Mato Grosso states) and a remote, minimally impacted area along the upper Japurá River (Amazonas state). Blood or liver samples from 88 primates representing 28 species were examined for HBV. HBV was detected in 17 of 49 primates (34.7%) from disturbed areas but in none of the 39 primates from the remote site. Human population density significantly predicted infection, and viral genotypes matched locally circulating human HBV strains, supporting human-to-primate spillover driven by deforestation and encroachment.

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Publication Details

Journal
EcoHealth
Published
2026-04-03
DOI
https://doi.org/10.1007/s10393-026-01787-5
Primary Topic
Hepatitis B Virus Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

First Report of Human Hepatitis B Virus (HBV) in Wild Neotropical Primates

Ana Maísa Passos-Silva, Luan Felipo Botelho-Souza, Izeni Pires Farias, Mariluce Rezende Messias et al.
EcoHealth
Hepatitis B Virus Studies
article

First Report of Human Hepatitis B Virus (HBV) in Wild Neotropical Primates

Ana Maísa Passos-Silva, Luan Felipo Botelho-Souza, Izeni Pires Farias, Mariluce Rezende Messias, Stephen R. Martin, Chrysoula Gubili, Jean P. Boubli, Deusilene Vieira, T. A. Burch, Tony H. Katsuragawa, Luiz S. Ozaki, Maisa da S. Araújo, Alcione de O. dos Santos, Luiz H. S. Gil, Juan M. V. Salcedo, André V. C. Pereira, Hani Rocha El Bizri
article en

Abstract

Globalization and environmental change are reshaping infectious disease dynamics, including reverse zoonotic transmission from humans to wildlife. We assessed hepatitis B virus (HBV) infection in wild New World primates from two Brazilian Amazon regions: an anthropogenically impacted area in southwestern Amazonia (Rondonia and Mato Grosso states) and a remote, minimally impacted area along the upper Japurá River (Amazonas state). Blood or liver samples from 88 primates representing 28 species were examined for HBV. HBV was detected in 17 of 49 primates (34.7%) from disturbed areas but in none of the 39 primates from the remote site. Human population density significantly predicted infection, and viral genotypes matched locally circulating human HBV strains, supporting human-to-primate spillover driven by deforestation and encroachment.

EcoHealth
Universidade Federal de Rondônia (BR), Virginia Commonwealth University (US), Instituto Federal de Educação, Ciência e Tecnologia de Rondônia (BR), Fundação Oswaldo Cruz (BR), University of Salford (GB), Universidade Federal do Amazonas (BR), Center for International Forestry Research (ID)
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Oswaldo Cruz, Instituto Chico Mendes de Conservação da Biodiversidade
Life in Land
Openalex Percentile: Top 30%
Hepatitis B Virus Studies
DOIOpen Access PDFOpenAlex
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