Resuscitation of a patient with progressive AIDS-related opportunistic infections complicated by MODS through multidisciplinary collaboration: case report

Globally, AIDS-related opportunistic infections complicated by multiple organ dysfunction syndrome (MODS) are associated with high mortality and are difficult to treat. This article summarizes the resuscitation experience of a patient with AIDS-related opportunistic infections-induced multiple MODS and explores the multidisciplinary collaborative treatment strategies. A retrospective analysis was conducted on a 37-year-old female patient withImmune Deficiency Syndrome (AIDS) who was admitted to the hospital due to “oliguria for 2 months and fever accompanied by dyspnea for 4 days”. She had a 10-year history of HIV infection without regular antiretroviral therapy. Complications such as renal failure, Co-infection of the lungs, respiratory failure, heart failure, liver injury, and cardiac arrest occurred. Multidisciplinary collaboration was carried out to promptly initiate comprehensive treatments including advanced life support and targeted anti-infection therapy. Rapid initiation of Antiretroviral Therapy (Rapid ART) was started after the patient’s condition stabilized. After 2 months of comprehensive treatment, the patient regained consciousness, was weaned off the ventilator, and showed improvement in liver and kidney functions and inflammatory markers, achieving clinical cure. Early recognition, strong advanced life support, targeted anti-infection therapy, and timely initiation of Rapid ART are the keys to the successful treatment of MODS caused by AIDS-related opportunistic infections. It suggests that for patients with AIDS-related opportunistic infections complicated by multiple organ failure, active comprehensive treatment can still lead to a good prognosis.

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Publication Details

Journal
AIDS Research and Therapy
Published
2026-04-03
DOI
https://doi.org/10.1186/s12981-026-00879-0
Primary Topic
Pneumocystis jirovecii pneumonia detection and treatment
Type
article
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article

Resuscitation of a patient with progressive AIDS-related opportunistic infections complicated by MODS through multidisciplinary collaboration: case report

Xiaofeng Wei, Shaowei Huang
AIDS Research and Therapy
Pneumocystis jirovecii pneumonia detection and treatment
article

Resuscitation of a patient with progressive AIDS-related opportunistic infections complicated by MODS through multidisciplinary collaboration: case report

Xiaofeng Wei, Shaowei Huang
article en

Abstract

Globally, AIDS-related opportunistic infections complicated by multiple organ dysfunction syndrome (MODS) are associated with high mortality and are difficult to treat. This article summarizes the resuscitation experience of a patient with AIDS-related opportunistic infections-induced multiple MODS and explores the multidisciplinary collaborative treatment strategies. A retrospective analysis was conducted on a 37-year-old female patient withImmune Deficiency Syndrome (AIDS) who was admitted to the hospital due to “oliguria for 2 months and fever accompanied by dyspnea for 4 days”. She had a 10-year history of HIV infection without regular antiretroviral therapy. Complications such as renal failure, Co-infection of the lungs, respiratory failure, heart failure, liver injury, and cardiac arrest occurred. Multidisciplinary collaboration was carried out to promptly initiate comprehensive treatments including advanced life support and targeted anti-infection therapy. Rapid initiation of Antiretroviral Therapy (Rapid ART) was started after the patient’s condition stabilized. After 2 months of comprehensive treatment, the patient regained consciousness, was weaned off the ventilator, and showed improvement in liver and kidney functions and inflammatory markers, achieving clinical cure. Early recognition, strong advanced life support, targeted anti-infection therapy, and timely initiation of Rapid ART are the keys to the successful treatment of MODS caused by AIDS-related opportunistic infections. It suggests that for patients with AIDS-related opportunistic infections complicated by multiple organ failure, active comprehensive treatment can still lead to a good prognosis.

AIDS Research and Therapy
Yunnan Maternal and Child Health (CN), Yunnan Provincial Infectious Disease Hospital (CN)
Good health and well-being
Openalex Percentile: Top 22%
Pneumocystis jirovecii pneumonia detection and treatment
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Resuscitation of a patient with progressive AIDS-related opportunistic infections complicated by MODS through multidisciplinary collaboration: case report — Xiaofeng Wei, Shaowei Huang · AIDS Research and Therapy (2026) | TGRS Research Map | TGRS