Multi‐Omics Analysis in Autoimmunity: Identification of MicroRNA Regulatory Networks and Cell‐Type‐Specific Dysregulations in Multiple Sclerosis and Type 1 Diabetes
T cell-fate commitment, apoptosis regulation, and migratory capacity. Notably, we identified miRNAs that regulate key transcription factors such as FOXP3, IRF4, and RORγt, potentially shaping T cell differentiation programs. Our results suggest that miRNA networks play a central role in orchestrating disease-specific dysregulation in AIDs. By elucidating these intricate regulatory mechanisms, our study provides a foundation for future therapeutic strategies targeting miRNAs in autoimmunity.
Authors
- M Foti
- Angela Stabilini
- Maria Letizia Fusco
- Giovanni Malerba (ORCID: https://orcid.org/0000-0001-8705-8560)
- Angela Papagna (ORCID: https://orcid.org/0000-0003-0723-9842)
- Martina Gallinaro
- R Rigolio (ORCID: https://orcid.org/0000-0001-7403-3698)
- Guido Cavaletti (ORCID: https://orcid.org/0000-0003-4128-2406)
- Manuela Battaglia (ORCID: https://orcid.org/0000-0003-4535-3152)
- Martina Gaia Cogo
- Jacopo Ronchi (ORCID: https://orcid.org/0000-0001-5520-4631)
- Davide Maria Trevisan
Institutions
- University of Verona (IT)
- Vita-Salute San Raffaele University (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- MedComm
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mco2.70647
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Cariplo
- Università degli Studi di Milano-Bicocca
- Ministero della Salute