Abstract 3681: Optimizing genetic/genomic health communication in cancer prevention through video development

Abstract Introduction: The Engagement Optimization Unit (EOU) of the USC Center for Optimizing Engagement in Colorectal Cancer Patients (COPECC), in partnership with the Patient Engagement Unit (PEU) and the Community Genetics Navigation Specialists (CoGENES) program, sought to improve educational materials for Hispanic participants in the ENLACE study before they received genetic testing results. Because colorectal cancer (CRC) incidence is rising in adults under 50 and is a leading cause of cancer death among Hispanic men, the team aimed to reduce disparities by providing clearer, more engaging information. Early listening groups (n=25) indicated a strong preference for video-based education, prompting development of a short film explaining the purpose and importance of genetic testing. Methods: The film was created in collaboration with the USC School of Cinema. The team identified four Key Messages to be woven into the film that outlines the purpose and meaning of genetic testing and design. A film visual outline was produced with patient interviews, content and order of graphic animations. Production work included preparation and actual filming of participants that provided relatable testimonials and cancer team clinicians that provide professional credibility about the purpose and meaning of genetic testing. Results: Focus groups had previously been conducted to better understand the preferred modality for presenting education materials. Individual comments specifically regarding the video revealed that there was a preference for the video format (5 focus groups 6/8 ,1/3, 3/3, 6/12/ and 3/3 comments specifically stated this preference). Based on this data as well as the literature, an 8-minute film was produced as an optimized format to present the information. The film content included testimonials by three participants, medical professionals (genetic counselor and physician) further explaining the importance of genetic testing, and animated graphics supporting the key messages being delivered. The film was assessed for logical information and content flow, and identification of key messages within the film, and relatability. Two language specific videos were created, one in Spanish and one in English - adding captions, animation, narration, and dubbing in both languages. The film is to be used in an education intervention comparing materials provided to cancer patients prior to receiving their genetic testing results. Conclusion: Based on previous research, this video will improve our understanding and retention of key genetic messages in colorectal cancer. The video has incorporated elements including information with visual movement, supported by captions and narration to deliver this information on genetic testing to the ENLACE participants. The creation of this video provides, at the very least, an alternative to education delivery mechanism (besides static written information). Citation Format: Elena B. Taylor, Charité N. Ricker, Daisy Hernandez, Itzya Ulloa, Rosa Barahona, Lourdes Baezconde-Garbanati. Optimizing genetic/genomic health communication in cancer prevention through video development [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 3681.