Multimodal Wearable and Survey Data Reveal Distinct Physiologic Profiles in Hypermobile-Ehlers Danlos Syndrome for Screening Advancements

-values < 0.05). Notably, autonomic metrics correlated with GI symptoms in the hEDS cohort (Spearman's ρ range: 0.38-0.60), and psychological symptoms in the healthy cohort (Spearman's ρ range: -0.47-0.41). Principal component analysis (PCA) of physiologic and symptom features clearly separated groups, supporting distinct physiologic profiles. Combination of GI symptom index and wearable monitoring show promise as a hybrid screening approach that could substantially shorten the time to diagnosis in this population.