Systemic translocation of <i>Staphylococcus aureus</i> promotes autoimmunity: implications in autoantibody-mediated poor immune reconstitution from antiretroviral therapy in HIV
translocation contributes to autoimmunity and impaired immune reconstitution in a subset of PWH on suppressive ART. These findings identify a previously unrecognized mechanism of immune failure and support a novel therapeutic strategy combining probiotics with ART to enhance immune recovery and reduce HIV-associated morbidity and mortality.
Authors
- Sonya L. Heath (ORCID: https://orcid.org/0000-0002-3826-0954)
- Reafa A. Hossain (ORCID: https://orcid.org/0000-0002-3113-8921)
- J. McKinnon
- Tabinda Salman (ORCID: https://orcid.org/0000-0002-2866-703X)
- Magnus Gisslén (ORCID: https://orcid.org/0000-0002-2357-1020)
- L. Ndhlovu
- Richard W. Price (ORCID: https://orcid.org/0000-0001-5429-6044)
- Ruth Adekunle (ORCID: https://orcid.org/0000-0001-5578-6571)
- D. Thor Johnson
- Wenhui Hu (ORCID: https://orcid.org/0000-0002-8886-7260)
- Zhenwu Luo
- Da Cheng
- Wei Jiang
Institutions
- San Francisco General Hospital (US)
- Medical University of South Carolina (US)
- Virginia Commonwealth University (US)
- Cornell University (US)
- Sahlgrenska University Hospital (SE)
- University of Alabama at Birmingham (US)
- Ralph H. Johnson VA Medical Center (US)
- Weill Cornell Medicine (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Virology
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1128/jvi.01965-25
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Center for Integrated Healthcare, U.S. Department of Veterans Affairs
- Mendez National Institute of Transplantation Foundation
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke