Ecoflex-hydrogel bilayer soft robot for pH-controlled drug protection and delivery

) nanoparticles within the silicone matrix further allows remote, non-invasive actuation under external magnetic fields. The platform exhibits excellent thermal stability at physiological temperature (36.5 °C) and demonstrates selective drug release under alkaline conditions representative of the intestinal microenvironment. Repeated pH cycling confirms robust structural integrity and highly reversible actuation over multiple cycles. Collectively, this work establishes the silicone-hydrogel bilayer soft robot as a versatile, magnetically actuated, pH-responsive drug delivery system with significant potential for precision cancer therapy.

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Publication Details

Journal
Materials Today Bio
Published
2026-04-03
DOI
https://doi.org/10.1016/j.mtbio.2026.103093
Primary Topic
Hydrogels: synthesis, properties, applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Ecoflex-hydrogel bilayer soft robot for pH-controlled drug protection and delivery

Hanbi Park, Yeonjae Lee, Jun Dong Park, ChangKyu Yoon et al.
Materials Today Bio
Hydrogels: synthesis, properties, applications
article

Ecoflex-hydrogel bilayer soft robot for pH-controlled drug protection and delivery

Hanbi Park, Yeonjae Lee, Jun Dong Park, ChangKyu Yoon, Eun Hui Jeong, Jiwoo Kim, Jinseo Yoon, Suho Lee, Jieun Kim, Minseong Kim, Jung Bok Lee, Donghoon Son
article en

Abstract

) nanoparticles within the silicone matrix further allows remote, non-invasive actuation under external magnetic fields. The platform exhibits excellent thermal stability at physiological temperature (36.5 °C) and demonstrates selective drug release under alkaline conditions representative of the intestinal microenvironment. Repeated pH cycling confirms robust structural integrity and highly reversible actuation over multiple cycles. Collectively, this work establishes the silicone-hydrogel bilayer soft robot as a versatile, magnetically actuated, pH-responsive drug delivery system with significant potential for precision cancer therapy.

Materials Today BioVol. 38
Sookmyung Women's University (KR), Pusan National University (KR)
National Research Foundation, Ministry of Education, Korea Basic Science Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Good health and well-being
Openalex Percentile: Top 34%
Hydrogels: synthesis, properties, applications
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