Ecoflex-hydrogel bilayer soft robot for pH-controlled drug protection and delivery
) nanoparticles within the silicone matrix further allows remote, non-invasive actuation under external magnetic fields. The platform exhibits excellent thermal stability at physiological temperature (36.5 °C) and demonstrates selective drug release under alkaline conditions representative of the intestinal microenvironment. Repeated pH cycling confirms robust structural integrity and highly reversible actuation over multiple cycles. Collectively, this work establishes the silicone-hydrogel bilayer soft robot as a versatile, magnetically actuated, pH-responsive drug delivery system with significant potential for precision cancer therapy.
Authors
- Hanbi Park
- Yeonjae Lee
- Jun Dong Park (ORCID: https://orcid.org/0000-0003-2918-5339)
- ChangKyu Yoon (ORCID: https://orcid.org/0000-0003-3716-4853)
- Eun Hui Jeong
- Jiwoo Kim (ORCID: https://orcid.org/0009-0000-0951-3847)
- Jinseo Yoon
- Suho Lee
- Jieun Kim
- Minseong Kim
- Jung Bok Lee
- Donghoon Son
Institutions
- Sookmyung Women's University (KR)
- Pusan National University (KR)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103093
- Primary Topic
- Hydrogels: synthesis, properties, applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Education
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea