Aging alters synergistic microRNA networks in exosomes to stimulate repair in lung injury and skin wound healing
experiments confirmed alterations in multiple downstream pathways, mediating reparative effects. These findings underscore age-dependent differences in stem cell-derived exosomes and demonstrate that synergistic miRNA cargo drives maximal efficacy.
Authors
- Simone Pereira-Simon
- Shahriar Shahzeidi
- Irena Pastar (ORCID: https://orcid.org/0000-0003-0197-6198)
- Sharon J. Elliot (ORCID: https://orcid.org/0000-0001-8622-1389)
- Sam Grimaldo (ORCID: https://orcid.org/0000-0003-1203-2790)
- Paola Catanuto
- M. Tomic-Canic
- Marilyn K. Glassberg (ORCID: https://orcid.org/0000-0003-1990-6614)
- Gina Civettini
- Xiaomei Xia
Institutions
- Florida Department of Health (US)
- University of Arizona (US)
- University of Miami (US)
- Loyola University Chicago (US)
- Banner Health (US)
Publication Details
- Journal
- Molecular Therapy — Nucleic Acids
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.omtn.2026.102927
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lester and Sue Smith Foundation
- Loyola University Chicago Stritch School of Medicine