Integrative Network Pharmacology, Molecular Docking, and In Vitro Insights Into the Mechanism of Finger Citron for Non‐Alcoholic Fatty Liver Disease
H-NMR and MS analyses. In vitro studies revealed that TMC effectively reduced lipid accumulation and oxidative stress induced by free fatty acids in HepG2 cells. Furthermore, RT-qPCR analysis showed that TMC modulated the mRNA expression of key target genes and lipid metabolism-associated genes, including CPT2, and APOC2, thereby substantiating the mechanistic basis of its therapeutic action. Collectively, these findings highlight the therapeutic potential of FC against NAFLD and provide a scientific basis for its further development as a promising NAFLD intervention.
Authors
- C. Y. Chen
- Qingpeng Li
- Xiaoling Chen
- Lin Zhou
- Fan Yang
- Dan Wang
- Huilong Sun
- Yongsheng Chen
- Hui He
Institutions
- Jinan University (CN)
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Food Science & Nutrition
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/fsn3.71695
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China