Integrative Network Pharmacology, Molecular Docking, and In Vitro Insights Into the Mechanism of Finger Citron for Non‐Alcoholic Fatty Liver Disease

H-NMR and MS analyses. In vitro studies revealed that TMC effectively reduced lipid accumulation and oxidative stress induced by free fatty acids in HepG2 cells. Furthermore, RT-qPCR analysis showed that TMC modulated the mRNA expression of key target genes and lipid metabolism-associated genes, including CPT2, and APOC2, thereby substantiating the mechanistic basis of its therapeutic action. Collectively, these findings highlight the therapeutic potential of FC against NAFLD and provide a scientific basis for its further development as a promising NAFLD intervention.

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Publication Details

Journal
Food Science & Nutrition
Published
2026-04-01
DOI
https://doi.org/10.1002/fsn3.71695
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Integrative Network Pharmacology, Molecular Docking, and In Vitro Insights Into the Mechanism of Finger Citron for Non‐Alcoholic Fatty Liver Disease

C. Y. Chen, Qingpeng Li, Xiaoling Chen, Lin Zhou et al.
Food Science & Nutrition
Liver Disease Diagnosis and Treatment
article

Integrative Network Pharmacology, Molecular Docking, and In Vitro Insights Into the Mechanism of Finger Citron for Non‐Alcoholic Fatty Liver Disease

C. Y. Chen, Qingpeng Li, Xiaoling Chen, Lin Zhou, Fan Yang, Dan Wang, Huilong Sun, Yongsheng Chen, Hui He
article en

Abstract

H-NMR and MS analyses. In vitro studies revealed that TMC effectively reduced lipid accumulation and oxidative stress induced by free fatty acids in HepG2 cells. Furthermore, RT-qPCR analysis showed that TMC modulated the mRNA expression of key target genes and lipid metabolism-associated genes, including CPT2, and APOC2, thereby substantiating the mechanistic basis of its therapeutic action. Collectively, these findings highlight the therapeutic potential of FC against NAFLD and provide a scientific basis for its further development as a promising NAFLD intervention.

Food Science & NutritionVol. 14(4)
Jinan University (CN), Guangdong Pharmaceutical University (CN), First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Openalex Percentile: Top 24%
Liver Disease Diagnosis and Treatment
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