Migraine induced by vascular K <sub>ATP</sub> channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation
channel activation into migraine pain and support a model in which migraine initiation arises from signalling at the vessel-to-neuron interface.Trial registrationClinicalTrials.gov; NCT04853797; Registered: 16-03-2021. Preclinical experiments were not preregistered beyond the animal ethical license (2017-15-0201-01358) from the Danish Animal Experiments Inspectorate.
Authors
- Mohammad Al‐Mahdi Al‐Karagholi (ORCID: https://orcid.org/0000-0003-1118-9665)
- Jawdat Abdulla (ORCID: https://orcid.org/0000-0002-9237-5314)
- Janu Thuraiaiyah (ORCID: https://orcid.org/0000-0002-7166-0976)
- David M. Kristensen (ORCID: https://orcid.org/0000-0003-0657-1632)
- Amalie Clement (ORCID: https://orcid.org/0000-0002-1301-9291)
- Zixuan Alice Zhuang (ORCID: https://orcid.org/0000-0002-0041-7389)
- Zahra Hakimzadeh (ORCID: https://orcid.org/0000-0002-3046-9753)
- Rogelio Domínguez-Moreno (ORCID: https://orcid.org/0000-0003-2788-8743)
- Sarah Louise Christensen (ORCID: https://orcid.org/0000-0002-7985-4783)
- Lili Kokoti (ORCID: https://orcid.org/0000-0002-9136-1367)
- Emil Gozalov
- Messoud Ashina
Institutions
- Roskilde University (DK)
- University of Copenhagen (DK)
- Inserm (FR)
- École des Hautes Études en Santé Publique (FR)
- Amager Hospital (DK)
- Hvidovre Hospital (DK)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- Cephalalgia
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1177/03331024261431770
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danmarks Grundforskningsfond
- Candys Foundation