Rh(III)-catalyzed C–H activation/annulation of fluoroalkylated benzhydrylamines with diarylalkynes enabled by amino directing groups
<h2>Abstract</h2> Fluoroalkyl groups hinder C−H activation due to steric and electronic effects. This study develops N-based directing groups that enable Cp*Rh(III)-catalyzed C−H activation/annulation of fluoroalkylated benzhydrylamines with alkynes, giving fluoroalkylated dihydroisoquinolines—promising scaffolds for drug discovery.
Authors
- Ryu Tadano
- Takeshi Yasui
- Yoshihiko Yamamoto
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Tetrahedron Chem
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.tchem.2026.100160
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development