Severe Tophaceous Gout After Decades of Progressive Disease: A Case Report

Tophaceous gout is a chronic, progressive manifestation of hyperuricemia characterized by urate crystal deposition in soft tissues and joints throughout the body. Although effective urate-lowering therapies exist, management can be challenging in patients with prior medical conditions such as renal insufficiency and chronic kidney disease. This often leads to medication intolerance with subsequent joint deformity and disability. Here, we present a 63-year-old man with severe, chronic tophaceous gout that has caused significant limitations. Despite years of treatment with various methods, this patient has yet to receive appreciable relief.

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Publication Details

Journal
Cureus
Published
2026-04-03
DOI
https://doi.org/10.7759/cureus.106367
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
Field-Weighted Citation Impact
0.00
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article

Severe Tophaceous Gout After Decades of Progressive Disease: A Case Report

Alexandra Jianu, Douglas Walsh, Nicholas Lorenz, Nicholas Jianu et al.
Cureus
Gout, Hyperuricemia, Uric Acid
article

Severe Tophaceous Gout After Decades of Progressive Disease: A Case Report

Alexandra Jianu, Douglas Walsh, Nicholas Lorenz, Nicholas Jianu, Skye Karastury, Grant Weiderman, Puneet Mann
article en

Abstract

Tophaceous gout is a chronic, progressive manifestation of hyperuricemia characterized by urate crystal deposition in soft tissues and joints throughout the body. Although effective urate-lowering therapies exist, management can be challenging in patients with prior medical conditions such as renal insufficiency and chronic kidney disease. This often leads to medication intolerance with subsequent joint deformity and disability. Here, we present a 63-year-old man with severe, chronic tophaceous gout that has caused significant limitations. Despite years of treatment with various methods, this patient has yet to receive appreciable relief.

CureusVol. 18(4)
University of Nevada, Las Vegas (US), University of California, Los Angeles (US), Lake Erie College of Osteopathic Medicine (US), Palmetto Research Center (US)
Good health and well-being
Openalex Percentile: Top 33%
Gout, Hyperuricemia, Uric Acid
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