Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis
therapeutic efficacy of DUB. In summary, our study not only identifies DUB as a promising anabolic agent against GIOP but also reveals a novel mechanistic link between purinergic signaling and bone redox homeostasis, highlighting the therapeutic potential of targeting the CD39/CD73/ADO axis for treating this and potentially other oxidative stress-associated skeletal disorders.
Authors
- Wencan Zhang (ORCID: https://orcid.org/0000-0002-0052-3106)
- Dingxin Zhang (ORCID: https://orcid.org/0000-0002-8089-6040)
- Yanguo Wang
- Peijie Hu
- Wenpeng Xu
- Haipeng Si
- Yu Xu
- Shangzhi Li
- Qian Sun
- Xiangyu Lin
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.03.062
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province
- Natural Science Foundation of Qingdao
- Medical and Health Science and Technology Development Project of Shandong Province