Anti‐Inflammatory Effect of miR‐197‐3p‐Loaded Microvesicles in Familial Mediterranean Fever Mouse Model

mouse model of FMF decreased the IL-1β level and the expression of CD11b and improved clinical inflammation manifestations. The results show that miR-197-3p-loaded MVs modulate inflammation, as well as improve phenotypic features of FMF, which is a promising, cell-free potential therapeutic strategy for autoinflammatory diseases. This study represents a preliminary proof-of-concept evaluation of miR-197-3p-loaded microvesicles in a murine FMF model, and further long-term and large-scale studies are required before clinical translation can be considered.