The Clinical Importance of Decreased Serum IL-38 and IL-41 Levels in Allergic Rhinitis

OBJECTIVE: This study aimed to evaluate the relationship between interleukin (IL)-38, IL-41, and allergic rhinitis (AR). METHODS: Forty outpatients with AR and 40 healthy controls (HC) were recruited. Data such as the sex and age of the participants were collected. IgE levels were detected and 15 allergens were tested in patients with AR. Blood was collected from the participants and serum IL-38, IL-41, IL-17 and IgE levels were measured using an enzyme-linked immunosorbent assay. RESULTS: < .0001), respectively. CONCLUSIONS: The decreased serum levels of IL-38 and IL-41 in outpatients with AR suggest that IL-38 and IL-41 may serve as potential indicators for the diagnosis of AR.