Evaluation of Stress Ulcer Prophylaxis Use Among Adult Patients Admitted to the Intensive Care Unit in Northwest Ethiopia Hospitals During 2024: A Multicenter Cross‐Sectional Study

Background and Aim: Stress-related mucosal bleeding among critically ill patients in intensive care unit (ICU) contributes substantially to morbidity and mortality. Despite growing concerns globally over inappropriate stress ulcer prophylaxis (SUP) use, limited data exist from Ethiopia, particularly in ICU settings. The objective of this study was to assess the appropriateness of SUP indications and associated factors among ICU-admitted patients in Northwest Ethiopia hospitals and to evaluate physicians' knowledge related to SUP prescribing practices. Methods: < 0.05% and 95% confidence intervals (CI). Results: = 0.001]. Conclusions: Inappropriate use of SUP was widespread among ICU patients in Northwest Ethiopia. Older age and prolonged hospitalization were significantly associated factors. Regular prescriber education, involvement of clinical pharmacists, and routine audit with feedback are recommended to reduce inappropriate SUP use, particularly among older patients and those with prolonged hospital stays.