Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066

statistical calculations. Further specific rotation analyses revealed the absolute configurations of both compounds 2 and 4 as 14 R and 15 R, while compound 3 was assigned as 14S and 15S. Antibacterial activity evaluated by the minimal inhibitory concentration (MIC) assay indicated that only compound 4 exhibited weak activity against the Gram-positive bacteria B. subtilis KCTC 1021 and K. rhizophila KCTC 1915, with MIC values of 64 μg/mL. Further, gambaoic acids B (2) and C (3) exhibited dose-dependent cytotoxicity toward Caco-2 cells, with gambaoic acid C (3) demonstrating a pronounced anti-invasive effect. These findings highlight the diverse bioactivities of the isolated hydroxyl fatty acids and reveal structural features underlying their antimicrobial and anticancer properties.

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Publication Details

Journal
The Journal of Antibiotics
Published
2026-04-03
DOI
https://doi.org/10.1038/s41429-026-00914-2
Primary Topic
Seaweed-derived Bioactive Compounds
Type
article
Field-Weighted Citation Impact
0.00

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article

Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066

Jeong-Hyeon Kim, Prima F. Hillman, Mücahit Varlı, Geum Jin Kim et al.
The Journal of Antibiotics
Seaweed-derived Bioactive Compounds
article

Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066

Jeong-Hyeon Kim, Prima F. Hillman, Mücahit Varlı, Geum Jin Kim, Hangun Kim, Hyukjae Choi, Chaeyoung Lee, Minyi Yoo, Sang-Ah Han, Songyi Lee, Ji Young Lee, Hunmin Lee, Rui Zhou, Sang-Jip Nam
article en

Abstract

statistical calculations. Further specific rotation analyses revealed the absolute configurations of both compounds 2 and 4 as 14 R and 15 R, while compound 3 was assigned as 14S and 15S. Antibacterial activity evaluated by the minimal inhibitory concentration (MIC) assay indicated that only compound 4 exhibited weak activity against the Gram-positive bacteria B. subtilis KCTC 1021 and K. rhizophila KCTC 1915, with MIC values of 64 μg/mL. Further, gambaoic acids B (2) and C (3) exhibited dose-dependent cytotoxicity toward Caco-2 cells, with gambaoic acid C (3) demonstrating a pronounced anti-invasive effect. These findings highlight the diverse bioactivities of the isolated hydroxyl fatty acids and reveal structural features underlying their antimicrobial and anticancer properties.

The Journal of Antibiotics
Ewha Womans University (KR), Gyeongju University (KR), Sunchon National University (KR), Dongguk University (KR), Yeungnam University (KR), Andalas University (ID), Pukyong National University (KR)
National Research Foundation, Ewha Womans University, Korea Basic Science Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Openalex Percentile: Top 31%
Seaweed-derived Bioactive Compounds
DOIOpen Access PDFOpenAlex
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