Can the <scp>HALP</scp> Score Be Used as a Prognostic Marker in Paediatric Patients With Cystic Fibrosis?

RATIONALE: Cystic fibrosis (CF) is characterised by chronic inflammation and malnutrition, significantly affecting disease progression and prognosis. The haemoglobin-albumin-lymphocyte-platelet (HALP) score reflects inflammatory and nutritional status, and has prognostic associations in various chronic diseases; its role in paediatric CF is unclear. OBJECTIVE: , MSKS, and BMI z-score), and (ii) subsequent 12-month outcomes (hospitalisation-requiring pulmonary exacerbations, PICU admission, and mortality) in children with CF. METHODS: was restricted to participants with acceptable spirometry. RESULTS: , although the effect size was modest and precision limited (adjusted OR 0.886, 95% CI 0.788-0.996; p = 0.043). CONCLUSIONS: HALP, reflecting nutritional and inflammatory status, may offer prognostic information in paediatric CF. Calculation from routine blood tests could make it a practical tool for identifying higher-risk individuals and informing clinical decision-making. Further large-scale studies are needed to validate its clinical utility in CF management.