Retroviral Transduction of Human CD4 <sup>+</sup> T Cells with Membrane-Attached IL-10 Generates Type 1-Like Regulatory T Cells
T cells with membrane-attached IL-10 (memIL-10) or memIL-10/CAR as a new method for generating large cell populations of high purity, stability, and antigen specificity displaying the main phenotypic and functional characteristics of Tr1 cells.
Authors
- Dayana Blokon-Kogan
- Hadas Weinstein-Marom (ORCID: https://orcid.org/0000-0002-2445-8222)
- Maya Levi-Mann
- Gideon Gross
- Shaul Davidson
Institutions
- Migal - Galilee Technology Center (IL)
- Tel Hai Academic College (IL)
Publication Details
- Journal
- Human Gene Therapy
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1177/10430342261437963
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- GentiBio