Tetracycline Resistance Pattern Among Lymphatic Filariasis‐Hyperendemic Communities in Southern Ghana: A Mixed‐Method Approach
Background and Aim: treatments. Methods: This cross-sectional study in Ghana's Ahanta West District enrolled 71 filarial lymphedema patients from four LF-hyperendemic communities. Structured questionnaires evaluated KAP on antibiotic use and resistance, complemented by microbiological analysis of wound swabs from 28 patients to profile the wound microbiome and assess tetracycline resistance. Results: gene in 34.1% (14) of isolates with Tm variation (69.27°C-73.06°C), suggesting variants. Conclusion: Multifaceted strategies are essential to curb tetracycline resistance and overuse. These include culturally adapted education to enhance antibiotic stewardship among patients and providers, optimized wound care protocols addressing polymicrobial infections through improved hygiene and tailored regimens, and ongoing resistance surveillance to track trends while promoting therapeutic alternatives.
Authors
- Amma Larbi (ORCID: https://orcid.org/0000-0002-3814-6924)
- Priscilla Osei‐Poku (ORCID: https://orcid.org/0000-0002-9187-2503)
- Emmanuel Kobla Atsu Amewu (ORCID: https://orcid.org/0000-0001-8214-3803)
- Mary Wilson
- Alexander Kwarteng (ORCID: https://orcid.org/0000-0002-0893-2908)
- Arnold Abakah (ORCID: https://orcid.org/0009-0000-4163-7612)
- Abdul Latif Koney Shardow
- Cynthia Adu‐Asiamah Kyerewaa
Institutions
- Kwame Nkrumah University of Science and Technology (GH)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- Koforidua Technical University (GH)
Publication Details
- Journal
- Health Science Reports
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/hsr2.72242
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00