Manganese-potentiated cGAS–STING activation with ATM/PRMT5 inhibition remodels the immunosuppressive microenvironment in osteosarcoma via bone-targeted delivery
-AP significantly inhibits OS progression and boosts systemic immune responses. This dual-action, bone-specific nanotherapeutic platform synchronized DNA-repair inhibition and Mn-enhanced immune-stimulation, offering a promising new approach for effective osteosarcoma treatment.
Authors
- Yuezhan Li
- Yong Liu (ORCID: https://orcid.org/0000-0001-6697-5052)
- Shijie Chen
- Lingpu Zhang
- Haihua Xiao
- Zhaochen Tong
- Yi Peng
- Dabao Xu
- Zixin Li
- Sijie Wen
- Dong Wang
- Jinglei Miao
- Weiguo Wang
Institutions
- Gynecologic Oncology Group (US)
- Central South University (CN)
- Hunan University (CN)
- National University of Defense Technology (CN)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Chinese Academy of Sciences (CN)
- Swiss Institute for Regenerative Medicine (CH)
- Beijing National Laboratory for Molecular Sciences (CN)
- Regenerative Medicine Institute (MX)
- Institute for Reproductive Health (US)
- Institute of Chemistry (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.03.032
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hunan Province
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University
- National Clinical Key Specialty Project Foundation