Pyrazolone Compounds as Promising Anticancer Agents for Colorectal Cancer: Synthesis, Antiproliferative Activity, and Mechanistic Insights
value of 8.2 μM. Molecular docking further supported these findings, showing favorable binding energy (-7.98 kcal/mol) compared to regorafenib (-7.13 kcal/mol). Collectively, these results highlight PL-13 as a promising lead compound for further optimization toward CRC therapy.
Authors
- Siva Murru (ORCID: https://orcid.org/0000-0002-1956-3079)
- Debajyoti Majumder
- Heba E. Elsayed (ORCID: https://orcid.org/0000-0001-5395-3081)
- Hassan Y. Ebrahim (ORCID: https://orcid.org/0000-0001-9057-4582)
- Atchimnaidu Siriki
- Ali Gholamian Moghaddam
- Khalid El Sayed
Institutions
- Louisiana State University (US)
- University of Louisiana at Monroe (US)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1002/cmdc.202500864
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Louisiana Biomedical Research Network